Showing posts with label MTHFR. Show all posts
Showing posts with label MTHFR. Show all posts

Saturday, November 9, 2013

Online Blood Testing and Vitamin D -

Vitamin D - It's NOT Just About Bones            

A growing body of research continues to demonstrate that Vitamin D deficiency is extremely common and may be the most common medical condition in the world.
It has been estimated that 50% of the general population and 80% of infants are deficient in Vitamin D. Latest research has estimated that approximately 1 billion people (1/7th of the world population) have inadequate levels of Vitamin D.

Vitamin D and its receptor are among one of the oldest chemicals ‘this thing called life’ uses to maintain biologic function. Virtually every tissue type in our body has receptors for Vitamin D – which points to how important Vitamin D is to our overall health and wellbeing. It’s true we humans have the capacity to synthesize Vitamin D in our body. However, based on the latest research showing how many of us are vitamin D ‘deficient’ the majority of us need additional amounts from the sun, our diet and / or supplements in order to maintain adequate levels. Vitamin D must interact with the Vitamin D Receptor (VDR), a nuclear hormone receptor in order to activate the active form of Vitamin D known as calcitrol. The action of Vitamin D and VDR work together in order orchestrate an estimated 3,000 - 30,000 genes that control cell growth, help sustain immune function and help regulate metabolic activity.

Vitamin D deficiency has been linked to increased risk for many common and serious diseases including cancer, depression, diabetes, cardiovascular disease, infections, arthritis and osteoporosis.

Diseases and Disorders Associated with Vitamin D Deficiency

• Alzheimer’s Disease
• Autism
• Autoimmune Disease (Multiple Sclerosis)
• Cardiovascular disease
• Cancer
• Chronic fatigue
• Chronic Pain (bone/muscle/joint)
• Cognitive impairment in seniors
• Crohn’s Disease
• Depression
• Diabetes type I & II
• Hypertension
• Inflammatory bowel diseases
• Low blood calcium levels
• Mood Disorders
• Osteoporosis/Osteomalacia
• Parkinson’s Disease
• Periodontal disease
• Pregnancy Complications (premature labor, birth defects, low birth weight)
• Respiratory Infections
• Rheumatoid arthritis
• Schizophrenia
• Stroke

Indicators Vitamin D Testing Should Be Evaluated 

• Bladder Problems
• Breast Feeding – (If levels are low in the mother)
• Chronic Musculoskeletal Pain – Persistent and non-specific
• Gastrointestinal Imbalances (Constipation /Diarrhea)
• Head Aches
• High Blood Pressure
• Geographic Area’s with elevated Urban pollution
• Depressive signs
• Poor Concentration
• Infants & Elderly
• Lack of Energy
• Muscle Wasting
• Individuals taking Vitamin D supplementation greater than 2,000 IU / day
• Individuals with medium to dark complexions
• Individuals who do not regularly receive 20 minutes of direct sunlight each day
• Weight Gain - BMI >25                                                                                                                              
   (Remember Vitamin D is fat soluble, it may get blocked in adipose (fat) tissue minimizing the body's  
   ability to use it)

How Often Should Vitamin D Testing Be Done

Vitamin D levels should be checked at least once a year especially in the late fall or beginning of winter. If you are taking Vitamin D supplements, supplementing, it is recommended vitamin D levels approximately every 3 months until you are in the optimal range.

Vitamin D Testing Without a Provider Visit -     


"Yes You Can Monitor Levels Yourself" 

http://www.mylabsforlife.com - Vitamin D 25-Hydroxy

Vitamin D Basics: This blood test measures Vitamin D 25 (OH) levels. Vitamin D, known as the "sunshine vitamin." Vitamin D is a fat-soluble prohormone that the body can synthesize as Vitamin D3 (cholecalciferol) when the skin is exposed to ultraviolet-B (UBV) rays from the sun. Vitamin D is needed for strong bones and teeth, Vitamin D helps your body absorb the amount of calcium and phosphorus it needs. It also has other roles in the body, including modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. Though controversial at times, research demonstrating the importance of Vitamin D3 continues to accumulate, while illuminating the threats that low levels pose to overall health and well-being. Low serum Vitamin D levels have been associated with a rise in the incidence of cardiovascular diseases, diabetes mellitus, depression, dental issues, cancer, osteoporosis, and periodontal disease, all of which are either considered risk factors for dementia and cognitive decline. Low Vitamin D levels also plays a role in hypertension, chronic pain, muscle weakness, muscle wasting, pre-term births as well as birth defects and autoimmune diseases and the list is mounting.
What's your level?




References

Here are some recommended sublingual Vitamin D supplements - Easy for anyone to take!
Suggested Vitamin D Supplement

High prevalence of vitamin D inadequacy and implications for health.
https://www.ncbi.nlm.nih.gov/pubmed/16529140

Scientists investigate possible connection between autism and vitamin D
http://www.environmentalhealthnews.org/ehs/news/2013/autism-and-vitamin-d

From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health.
https://www.ncbi.nlm.nih.gov/pubmed/18689389

Vitamin D — Effects on Skeletal and Extraskeletal Health and the Need for Supplementation.
http://www.mdpi.com/2072-6643/5/1/111

Etiopathogenesis of autism spectrum disorders: Fitting the pieces of the puzzle together.
http://www.ncbi.nlm.nih.gov/pubmed/23622947

Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline.
http://www.ncbi.nlm.nih.gov/pubmed/21646368

Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Calcium and Vitamin D.
http://www.iom.edu/Activities/Nutrition/DRIVitDCalcium.aspx

The Pharmacology of Vitamin D.
http://www.astro.hr/_t_07/lit_08_bio.chem/Vitamin%20D,%20Third%20Edition.pdf

Evaluation, Treatment, and Prevention of Vitamin D Deficiency:
An Endocrine Society Clinical Practice Guideline
https://www.endocrine.org/sitecore%20modules/web/~/media/endosociety/Files/Publications/Clinical%20Practice%20Guidelines/FINAL-Standalone-Vitamin-D-Guideline.pdf#search=%22vitamin%20d%20levels%22

Vitamin D – University of Maryland Medical Center
http://umm.edu/health/medical/altmed/supplement/vitamin-d

Disclaimer
The statements on this site have not been evaluated by the Food and Drug Administration. Any products mentioned or discussed on this site are not intended to diagnose, treat, cure, or prevent any disease. The information on this site is not intended to be a substitute for professional medical advice. The health related and medical information and on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician, client-nurse practitioner or patient-pharmacist relationship, and should not be used as a substitute for professional diagnosis and treatment. It is recommended the reader of this site consult with a qualified health care provider of their choice when using any information obtained from this site and affiliate sites. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition.

In concert with evidence-based information, this site proposes certain theoretical methods of functional and nutritional support that may not be supported by conventional or mainstream medicine. Any information obtained from this site is left to the discretion and is the sole responsibility of the user of this site.

The contributors of this site cannot be held responsible for the information or any inadvertent errors or omissions of the information. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented. If you do not agree to the foregoing terms and conditions, you should not enter this site. The contributors of this site shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site.

Friday, October 25, 2013

MTHFR & Homocysteine - Where's The Fire

MTHFR & Homocysteine – Methylation Malfunction 

Inflammation & Methylation 

As discussed in a previous post, MethylenetetrahydrofolateReductase (MTHFR) is an inherited genetic variant that researchers call a polymorphism (SNP). Growing research demonstrates that up to half of all Americans may carry at least one genetic variation (C677T & A1298C) known as MTHFR. This variation prevents the body, including the brain, from being able to properly use folic acid, which disrupts a process known as Methylation.

Methylation is a critical biologic process that requires adequate amounts of folic acid, Vitamin B6 and Vitamin B12 which act as cofactors in key enzymes that produce and balance neurotransmitters such as serotonin. Methylation is also extremely important for other bodily functions such as detoxifying homocysteine.

Homocysteine is a byproduct of cellular metabolism and is generated when methionine (amino acid found in fish, meats and dairy) is metabolized to help make proteins and to maintain tissues. When adequate levels of B Vitamins are available, they recycle left over homocysteine into methionine and the cycle repeats itself. If the Methylation process in not working correctly (MTHFR +/+), elevated levels of homocysteine may occur and become a risk factor for many chronic diseases such as heart disease, Alzheimer’s disease, Parkinson’s disease, stroke and debilitating migraines. So what’s in common with all of these health challenges?

                                                      INFLAMMATION   


Simply put, elevated levels of homocysteine accelerate inflammatory disease processes.
Increased inflammation translates to an accelerated aging process!

Research has demonstrated that an elevated homocysteine levels have been linked to telomere damage. (Telomeres are protective caps at the end of the chromosome that shorten with age). Research has also shown a direct link to elevated homocysteine levels and damage to the hippocampus, the area of the brain that plays a crucial role in memory formation. It is well documented that elevated levels of homocysteine may be related to a deficiency of three necessary B Complex Vitamins B6, Folic Acid & B12. This deficiency inhibits the body's ability to process dietary protein. The typical American diet is filled with nutrient deficient foods. Taking B vitamins may not lower homocysteine levels, however they play a critical role in balancing homocysteine levels.

What You Can Do: Right Now


  • Lifestyle habits such as smoking and alcohol consumption may also affect homocysteine levels. Changes in these life style factors may reduce homocysteine levels and hopefully reduce the threat to cardiovascular health.

  • Test Your Self: If you are interested in testing without a doctors visit or would simply like to learn more, click here: www.mylabsforlife.com


RESOURCES

Homocysteine levels and leukocyte telomere length

Effect of lifestyle factors on plasma total homocysteine concentrations in relation to MTHFR (C677T) genotype.

Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study.

Plasma Homocysteine Concentration, C677T MTHFR Genotype, and 844ins68bp CBS Genotype in You Adults With Spontaneous Cervical Artery Dissection and Atherothrombotic Stroke.

Migraine Mediates the Influence of C677T MTHFR Genotypes on Ischemic Stroke Risk With a Stroke-Subtype Effect.




Disclaimer

The statements on this site have not been evaluated by the Food and Drug Administration. Any products mentioned or discussed on this site are not intended to diagnose, treat, cure, or prevent any disease. The information on this site is not intended to be a substitute for professional medical advice. The health related and medical information and on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician, client-nurse practitioner or patient-pharmacist relationship, and should not be used as a substitute for professional diagnosis and treatment. It is recommended the reader of this site consult with a qualified health care provider of their choice when using any information obtained from this site and affiliate sites. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition.

In concert with evidence-based information, this site proposes certain theoretical methods of functional and nutritional support that may not be supported by conventional or mainstream medicine. Any information obtained from this site is left to the discretion and is the sole responsibility of the user of this site. 

The contributors of this site cannot be held responsible for the information or any inadvertent errors or omissions of the information. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented. If you do not agree to the foregoing terms and conditions, you should not enter this site. The contributors of this site shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site.